This online short course that will look at synthetic and scale up aspects of making and using Grignard reagents. The course will be in two sections of 60-90 minutes held over two consecutive days as follow:

Monday, September 4th | 2.00 – 5.00 pm (UK)
Session 1: Making Grignard reagents and safety aspects of making and handling Grignard reagents.

This presentation will cover the main ways for preparing organomagnesium compounds, and consider their relative reactivity and stability once prepared. In addition the safety issues associated with making organomagnesium compounds will be discussed. The presentation will use real life case studies to illustrate the various aspects of preparation, stability and safety.

Making Grignard reagents on scale
Safety issues
Tuesday, September 5th | 2.00 – 5.00 pm (UK)
Session 2: Recent examples of using Grignard reagents, and making Grignard reagents in continuous flow mode.

This presentation will cover recent developments in the use of Grignard reagents such as Kumada and Negishi couplings along with the preparation and use of Grignard reagents in flow with particular emphasis on the scale up of flow processes for the preparation of Grignard reagents via industrial case studies.

Recent examples of using Grignard reagents
Making Grignard reagents in continuous flow mode.
This online course will be of interest to anyone involved in synthetic organic chemistry, since every chemist will run at least one Grignard reaction in their life.



Speaker: Dr John Studley