In the MRCS OSCE exam, the surgical trainees are expected to have a good working knowledge of general physiological principles, core knowledge of the physiology of specific systems and an understanding of their application in surgical practice. This intensive one-day revision course will provide the candidates with an overview of basic physiological principles, and the physiology of the respiratory, cardiovascular, renal, endocrine, gastrointestinal and the central nervous systems. The course will be delivered using a series of interactive lectures with OSCE focus and OSCE scenarios. All major areas as stipulated in the MRCS Part B syllabus will be covered.Topics coveredGeneral physiological principles:Acid-base imbalance (metabolic and respiratory acidosis/alkalosis) and their managementFluid balance and fluid replacement therapyBleeding and coagulationManagement of sepsis and septic shockHomeostasis and thermoregulationCardiovascular system:Cardiac pressure cycleControl of cardiac outputBlood pressure and its control mechanismsIonotropesSurgical in patients with cardiovascular pathologiesRespiratory system:Normal ventilatory cycleCauses and management of post-operative respiratory failureIntermittent positive pressure ventilationAcute (adult) respiratory distress syndromeApplied critical care physiology during the peri-operative periodEndocrine system:Thyroid hormones, hypothyroidism and hyperthyroidismParathyroid hormones, their disorders and calcium metabolismGlucose homeostasis and diabetesFunction of the pituitary and adrenal glandsErythropoietinRenal system:Renal autoregulationRenin-angiotensin systemTypes and management of renal failureCentral nervous system:Cerebral autoregulationSpace-occupying lesionsHead Injuries and managementGastrointestinal system:Gut hormonesPancreatic functionPeristalsis and ileusBurns:Assessment, pathophysiology and principles of managementManagement of patients undergoing surgery:Principles of Epidural Anaesthesia/AssessmentPain pathwaysResuscitation, Temperature Regulation and Hypothermia