Biomarkers are increasingly required for effective research into neurodegenerative diseases. They are critical for diagnosis, disease monitoring and will be key for measuring target engagement of disease modifying therapies.PhD students working in the field of neurodegeneration require a working knowledge of a range of biomarkers to correctly interpret scientific literature and to design and conduct successful and ambitious research studies. University College London and University of Gothenburg are leading international centres with complementary expertise in fluid and imaging biomarkers. This collaboration would be expected to strengthen the quality of biomarker training across both institutions and beyond, as well as fostering new research collaborations and providing delegates with outstanding networking opportunities. Speakers:We are pleased to host a truly outstanding selection of world leading speakers:Ulf Andreasson, University of Gothenburg, Sweden Nicholas Ashton, University of Gothenburg, Sweden/King’s College London, UK Kaj Blennow, University of Gothenburg, Sweden Stephen Carter, Wolfson Molecular Imaging Centre, University of Manchester, UK Nick Fox, University College London, UK Johan Gobom, University of Gothenburg, Sweden Jörg Hanrieder, University of Gothenburg, Sweden John Hardy, University College London, UK Kerstin Heurling, University of Gothenburg, Sweden William Jagust, University of California, Berkeley, USA Tammaryn Lashley, University College London, UK Hanna Mann Olink Proteomics Niklas Mattsson, Lund University, Sweden Joana Pereira, Karolinska Institute, Sweden Erik Portelius, University of Gothenburg, Sweden Jonathan Schott, University College London, UK Andrea Varrone, Karolinska Institute, Sweden Henrik Zetterberg, University of Gothenburg, Sweden/University College London, UK Course direction:Ross Paterson is Clinical Lecturer at UCL Institute of Neurology. Michael Scholl is Associate Professor at the University of Gothenburg.Course content:pipette techniqueThe aims will be to provide basic and practical knowledge of fluid and brain imaging-based biomarkers for neurodegenerative diseases. Participants will be expected to achieve a broad understanding of the following advanced brain imaging and neurochemistry technologies used as research and clinical tools in neurodegenerative diseases:- Neurochemistry (liquid-based biomarkers):- Biomarkers in cerebrospinal fluid- Biomarkers in blood- Structural and functional magnetic resonance imaging (MRI)- Positron emission tomography (PET)- Single-photon emission computed tomography (SPECT) Learning outcomes:After completing the course the student is expected to be able to:· Explain basic concepts in image-based and fluid-based biomarker research.· Describe how different biomarkers relate to each other in a temporal, pathogenic, and regional (anatomical) context of different neurodegenerative diseases.· Conduct the planning of a project within their own research area where the use of the discussed biomarkers is described.· Use basic tools to evaluate biomarker data· Interpret biomarker profiles in different neurodegenerative diseases.· Understand when particular biomarkers/methods can & cannot be applied· Analyze the predictive value of the respective biomarkers in different conditions.Eligibility:No exclusion criteria, but the course is aimed at PhD candidates. Applications will be accepted from any institution.Cost:Students will be expected to contribute £200 to participate. This will include all lectures, a hot two course lunch on Wednesday 3rd to Friday 5th and tea and coffee throughout the course. This will be payable through the UCL online store. Accommodation will not be provided but students will be provided with a list of affordable accommodation, some eligible for UCL student discount.